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The history of organic synthesis is generally traced back to W ö hler ' s synthesis of the natural product urea from ammonium isocyanate in 1828. This laid toThe concepts and practice of Green Chemistry have developed over nearly 20 years into a globe-spanning endeavor aimed at meeting the ''triple bottom line''— ​To define ​“​green chemistry​” ​and place its birth and expansion in an historical context. ​∙. To introduce the principles of green chemistry, Green Chemistry Principles and Brief History. Green chemistry traces back several decades and can be linked to impactful environmental activists, such as Rachel