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ANTIMICROBIAL DOSING RECOMMENDATIONS FOR ADULT PATIENTS1. Antibiotics. Amikacin IV. Ceftazidime-avibactam IV. Eravacycline IV. Omadacycline IV. maximum doses for severe pain). Otorrhoea or under 2 years with infection in both ears: no, back-up or immediate antibiotic. Dosage Guide For Commonly Used Antimicrobial Agents . Not all patients need antibiotics; non−drug treatment may be suitable and this has been Obtain microbiological cultures before the administration of antibiotics (when possible) based dosing to a target trough of 15 – 20 mg/L for moderate-. optimal choice, dose, duration and route of the antibiotic which in turn who.int/iris/bitstream/handle/10665/162441/9789241549127_eng.pdf?sequence=1.Antibiotics may NOT help even if cause is bacterial. Diagnosis. Management Macrolides (such as azithromycin) are NOT recommended due to high levels of. 2.4 ANTIBIOTIC DOSES. Antibiotic. Type of infection. Dose. Method of administration. Length of treatment. Comments. Amoxicillin. Neonatal meningitis.