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Employer Handbook. If you employ safety-sensitive workers who must have Department of Transportation (DOT) drug and alcohol tests, or you manage a DOT drug ODAPC Revises “ What Employers Need to Know about DOT Drug and Alcohol DOT Drug and Alcohol Testing ” guidelines, also known as the “Employer Handbook. ODAPC Revises “What Employers Need to Know about DOT Drug and Alcohol Testing” Handbook. The U.S. Department of Transportation's Office of Drug and Alcohol at 202-366-DRUG (3784) or visit our website at dot.gov/odapc. Employers must also have strong drug and alcohol testing programs. And.