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Centers for Disease Controls and Prevention and the National Institutes of Health Biosafety in Microbiological and Biomedical Laboratories (BMBL), 5th EditionThe principle and scope of these guidelines cover the use of GMMs in containment at pilot and industrial scales according to GMM classification, together with Biosafety guidelines aiming at- • Regulating rDNA research with organisms that have least or no adverse effect. Minimizing the possibilities of occasional The rDNA Biosafety Guidelines Of India. Page 5. Institutional biosafety committee (IBSC)- controls research It provides regulatory control to the.